Hematopoietic colony-stimulating factors: new players in tumor–nerve interactions
نویسندگان
چکیده
منابع مشابه
Pioneer of hematopoietic colony-stimulating factors: Leo Sachs (1924-2013).
It is with great sorrow that we write about the demise of Leo Sachs, the Otto Meyerhof Professor of Molecular Biology, friend, colleague and brilliant scientist. Leo was born in Leipzig, Germany in 1924, emigrated with his family from Nazi Germany to England in 1933, and reached Israel in 1952. He began studying agricultural botany at the University of Wales, became fascinated by genetics and d...
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Previous in vitro investigations on enriched human hematopoietic progenitors have led to the conclusion that the purified recombinant multipoietins, interleukin 3 (IL-3) and granulocyte-macrophage colony-stimulating factor (GM-CSF) can alone induce the formation of colonies from a variety of multipotent and lineage committed progenitors. Since fetal calf serum was included in these cultures and...
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Mitogenic stimulation in vitro of mouse T lymphocytes induces the production of the hematopoietic cytokines granulocyte-macrophage colony-stimulating factor and IL-3. The present experiments showed that simple crowding of murine spleen or lymph node cells was a sufficient inducing stimulus. Crowding did not have this consequence for thymus or marrow cells or spleen cells from nu/nu or Rag-1-/- ...
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Background: Recent studies have shown that bone marrow mesenchymal stem cells (BMSCs) have a putative ability to promote neurogenesis and produce behavioral and functional improvement. Our previous study demonstrated that co-treatment of granulocyte colony-stimulating factor (G-CSF) and BMSCs have beneficial effects on Parkinson's models. The main purpose of this research was to investigate the...
متن کاملColony stimulating factors and macrophage heterogeneity
Macrophages or mononuclear phagocytes are heterogeneous populations present throughout the body which can adapt quite dramatically to the surrounding milieu, both in the steady state and during immune/inflammatory responses. To assist in our understanding of this diversity, they have been classified into polarization or “activation” states, termed M1 and M2, respectively. This in vitro classifi...
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ژورنال
عنوان ژورنال: Journal of Molecular Medicine
سال: 2010
ISSN: 0946-2716,1432-1440
DOI: 10.1007/s00109-010-0697-z